Bernabeu, ManuelTaghi Gharibzahedi, Seyed MohammadGanaiee, Arsheed A.Macha, Muzafar A.Dar, Basharat N.Castagninia, Juan M.García Bonillo, CristinaMeléndez Martínez, Antonio J.Altintas, ZeynepBarba, Francisco J.2023-09-142023-09-142024Bernabeu, M., Gharibzahedi, S. M. T., Ganaie, A. A., Macha, M. A., Dar, B. N., Castagnini, J. M., Garcia-Bonillo, C., Meléndez-Martínez, A. J., Altintas, Z., & Barba, F. J. (2024). The potential modulation of gut microbiota and oxidative stress by dietary carotenoid pigments. Critical Reviews in Food Science and Nutrition, 64(33), 12555-12573. https://doi.org/10.1080/10408398.2023.22543831040-83981549-7852http://hdl.handle.net/11268/12287Gut microbiota plays a crucial role in regulating the response to immune checkpoint therapy, therefore modulation of the microbiome with bioactive molecules like carotenoids might be a very effective strategy to reduce the risk of chronic diseases. This review highlights the bio-functional effect of carotenoids on Gut Microbiota modulation based on a bibliographic search of the different databases. The methodology given in the preferred reporting items for systematic reviews and meta-analyses (PRISMA) has been employed for developing this review using papers published over two decades considering keywords related to carotenoids and gut microbiota. Moreover, studies related to the health-promoting properties of carotenoids and their utilization in the modulation of gut microbiota have been presented. Results showed that there can be quantitative changes in intestinal bacteria as a function of the type of carotenoid. Due to the dependency on several factors, gut microbiota continues to be a broad and complex study subject. Carotenoids are promising in the modulation of Gut Microbiota, which favored the appearance of beneficial bacteria, resulting in the protection of villi and intestinal permeability. In conclusion, it can be stated that carotenoids may help to protect the integrity of the intestinal epithelium from pathogens and activate immune cells.spaMicrobioma gastrointestinalDieta macrobióticaCarotenoidesjournal article10.1080/10408398.2023.2254383restricted accessMicrobiologíaNutriciónGoal 3: Ensure healthy lives and promote well-being for all at all agesGoal 10: Reduce inequality within and among countries