TY - JOUR 
A1 - Martínez de Vega, Vicente
AU - Jiménez de la Peña, Mar
AU - Carrascoso, Javier
AU - Rubio Alonso, Margarita
AU - Bachiller, Juan
AU - Martínez Chamorro, Carmen
AU - Recio Rodríguez, Manuel
T1 - The probably use of MR-spectroscopy and diffusion weighted-MRI of bone marrow for treatment monitoring in patients with chronic lymphatic leukemia
Y1 - 2021
SN - 2692-4684
UR - http://hdl.handle.net/11268/9916
AB - Objectives: To assess the usefulness of proton MR-spectroscopy (1H-MRS) and diffusion-weighted MRI (DW-MRI) sequences in the follow-up of CLL-patients with chemotherapy treatment. The monitoring of CLL-patients susceptible to chemotherapy treatment is complicated due to the difficulty in assessing the response to treatment. Chemotherapy leads to changes in bone marrow composition and these changes can be evaluated by functional MR-sequences.

Methods: 23 patients diagnosed with CLL by our hospital’s Hematology Service underwent a lumbar MR prior and post-chemotherapy applying 1H-MRS and DW-MRI. The concentrations of water and lipids were quantified applying the quantification program LCModel. The Apparent Diffusion Coefficient (ADC) values were calculated with the Functool program (GE). The Wilcoxon sign test was used to compare pre and post treatment results, considering statistically significant P values lower than 0.05.

Results: Responder patients decreased the ratio H2O/lipids concentration measured with 1H-MRS and increased the ADC value on DW-MRI in post-treatment studies (P<0.05). Patients without response increased the ratio and decreased the ADC values or did not modify the data.

Conclusion: 1H-MRS and DW-MRI of spinal bone marrow are non-invasive and repeatable techniques that might help in follow-up monitoring of patients with CLL.
KW - Leucemia linfoide
KW - Espectroscopía de resonancia magnética
KW - Cáncer
KW - Tratamiento médico
KW - Tecnología médica
LA - eng
ER -