TY - JOUR 
A1 - Martín Pérez, Laura
AU - Lucas Moreno, Beatriz de
AU - Bernal, Aurora
AU - González Gálvez, Beatriz
T1 - Adipokines disrupt cardiac differentiation and cardiomyocyte survival
Y1 - 2020
SN - 0307-0565

UR - http://hdl.handle.net/11268/9875
AB - Background: The role of adipose tissue in the pathophysiology of cardiovascular disease remains a major subject of research. The objective of the present study was to dissect the molecular mechanisms that regulate the survival and differentiation of cardiac cells in an obese environment.

Material and methods: We isolated murine/human cardiac cells from adult hearts of control and obese mice/subjects and analyzed the communication between cardiac cells and adipocytes in vitro, as well as the effects on their main functions such as survival and differentiation.

Results: We found that the presence of visceral or subcutaneous adipocytes in the environment of cardiomyocytes or cardiac precursors provoked apoptosis or blocked differentiation, respectively, and these effects were mediated by secreted adipokines. Remarkably, cardiac precursors changed their fate and differentiated into mature adipocytes, contributing to the overall increase in adipose cell content. Inhibiting the adipokines TNF-α, visfatin, or HMGB1 could block the deleterious effects of adipokines on cardiac cells.

Conclusions: Our findings demonstrate that mouse and human visceral adipose tissue contributes negatively to the homeostasis and regeneration of the heart. Moreover, our results suggest that blocking the action of certain adipokines might enhance cardiac differentiation and survival.
KW - Fisiopatología
KW - Miocitos Cardíacos
KW - Obesidad
KW - Enfermedad cardiovascular
KW - Fisiología
KW - Biología
LA - eng
ER -