TY - JOUR 
A1 - Rodríguez Sánchez, Elena
AU - Navarro García, José Alberto
AU - Aceves Ripoll, Jennifer
AU - González Lafuente, Laura
AU - Corbacho Alonso, Nerea
AU - Baldán Martín, Montserrat
AU - Madruga, Felipe
AU - Álvarez Llamas, Gloria
AU - Barderas, María G.
AU - Ruilope Urioste, Luis Miguel
AU - Ruiz Hurtado, Gema
T1 - Analysis of global oxidative status using multimarker scores reveals a specific association between renal dysfunction and diuretic therapy in older adults
Y1 - 2021
SN - 1079-5006
UR - http://hdl.handle.net/11268/9849
AB - Aging and chronic kidney disease (CKD) are important interrelated cardiovascular risk (CVR) factors linked to oxidative stress, but this relationship has not been well studied in older adults. We assessed the global oxidative status in an older population with normal to severely impaired renal function. We determined the oxidative status of 93 older adults (mean age 85 years) using multimarker scores. OxyScore was computed as index of systemic oxidative damage by analyzing carbonyl groups, oxidized low-density lipoprotein, 8-hydroxy-2'-deoxyguanosine and xanthine oxidase activity. AntioxyScore was computed as index of antioxidant defense by analyzing catalase and superoxide dismutase (SOD) activity and total antioxidant capacity. OxyScore and AntioxyScore were higher in subjects with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m 2 than in peers with eGFR >60 mL/min/1.73m 2, with protein carbonyls, catalase and SOD activity as major drivers. Older adults with a recent cardiovascular event had similar OxyScore and AntioxyScore as peers with eGFR >60 mL/min/1.73m 2. Multivariate linear regression analysis revealed that both indices were associated with decreased eGFR independently of traditional CVR factors. Interestingly, AntioxyScore was also associated with diuretic treatment, and a more pronounced increase was seen in subjects receiving combination therapy. The associations of AntioxyScore with diuretic treatment and eGFR were mutually independent. In conclusion, eGFR is the major contributor to the imbalance in oxidative stress in this older population. Given the association between oxidative stress, CKD and CVR, the inclusion of renal function parameters in CVR estimators for older populations, such as the SCORE-OP, might improve their modest performance.
KW - Fallo renal crónico
KW - Insuficiencia cardíaca
KW - Anciano
KW - Sistema endocrino
KW - Enfermedad cardiovascular
KW - Anciano
LA - eng
ER -