TY - JOUR 
A1 - García Laorden, María Isabel
AU - Lorente Balanza, José Ángel
AU - Flores, Carlos
AU - Slutsky, Arthur S.
AU - Villar, Jesús
T1 - Biomarkers for the acute respiratory distress syndrome: How to make the diagnosis more precise
Y1 - 2017
SN - 2305-5839

UR - http://hdl.handle.net/11268/9797
AB - The acute respiratory distress syndrome (ARDS) is an acute inflammatory process of the lung caused by a direct or indirect insult to the alveolar-capillary membrane. Currently, ARDS is diagnosed based on a combination of clinical and physiological variables. The lack of a specific biomarker for ARDS is arguably one of the most important obstacles to progress in developing novel treatments for ARDS. In this article, we will review the current understanding of some appealing biomarkers that have been measured in human blood, bronchoalveolar lavage fluid (BALF) or exhaled gas that could be used for identifying patients with ARDS, for enrolling ARDS patients into clinical trials, or for better monitoring of patient's management. After a literature search, we identified several biomarkers that are associated with the highest sensitivity and specificity for the diagnosis or outcome prediction of ARDS: receptor for advanced glycation end-products (RAGE), angiopoietin-2 (Ang-2), surfactant protein D (SP-D), inteleukin-8, Fas and Fas ligand, procollagen peptide (PCP) I and III, octane, acetaldehyde, and 3-methylheptane. In general, these are cell-specific for epithelial or endothelial injury or involved in the inflammatory or infectious response. No biomarker or biomarkers have yet been confirmed for the diagnosis of ARDS or prediction of its prognosis. However, it is anticipated that in the near future, using biomarkers for defining ARDS, or for determining those patients who are more likely to benefit from a given therapy will have a major effect on clinical practice.
KW - Síndrome respiratorio agudo grave
KW - Técnicas de diagnóstico del sistema respiratorio
KW - Biomarcadores
KW - Aparato respiratorio
KW - Enfermedad
KW - Medicina preventiva
LA - eng
ER -