TY - JOUR 
A1 - Ruiz, Jonatan R.
AU - Castillo, Ruth
AU - Labayen, Idoia
AU - Moreno López, Luis A.
AU - García Fuentes, Miguel
AU - González Lamuno, Domingo
AU - Álvarez Granda, Jesús L.
AU - Lucía Mulas, Alejandro
AU - Ortega, Francisco B.
AU - Avena Study Group
T1 - Individual and Combined Effects of ApoE and MTHFR 677C/T Polymorphisms on Cognitive Performance in Spanish Adolescents: The AVENA Study RID C-7661-2009
Y1 - 2010
SN - 00223476
UR - http://hdl.handle.net/11268/977
AB - Objective To examine the individual and combined associations of ApoE and MTHFR 677C/T polymorphisms with cognitive performance in adolescents. Study design The study comprised 412 Spanish adolescents (13 to 18.5 years of age). Cognitive performance (verbal, numeric and reasoning abilities, and an overall score) was measured by the Spanish-version of the SRA-Test of Educational-Ability. Results We observed no differences in the cognitive performance study variables in adolescents carrying or not carrying the ApoE epsilon 4 variant. Adolescents without the MTHFR 677TT genotype had significantly better cognitive performance than their TT peers. The analysis of the combined effect of these polymorphisms revealed that those individuals carrying both the ApoE epsilon 4 variant and the MTHFR 677TT genotype had significantly worse cognitive performance than their peers with other genotype combinations. These findings were independent of sex, age pubertal status, socioeconomic status, physical activity, and skipping breakfast. Conclusions The results of the present study suggest that the ApoE epsilon 4 alone is not associated with cognitive performance in adolescents. Individuals with the MTHFR 677TT genotype had slightly impaired cognitive performance, whereas we observed a combined effect of both the ApoE epsilon 4 variant and the MTHFR 677TT genotype on cognitive performance. More research is needed in larger population samples to corroborate our findings. (J Pediatr 2010;156:978-84).
KW - Cognición
KW - Psicología del adolescente
LA - eng
ER -