TY - JOUR 
A1 - Fidel Nicolás, Lolo
AU - Rius Leiva, Cristina
AU - Casas Tintó, Sergio
T1 - Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages
Y1 - 2017
SN - 2046-6390
UR - http://hdl.handle.net/11268/9768
AB - Cellular interactions are critical during development, tissue fitness
and epithelial tumor development. The expression levels of specific
genes confer to tumoral cells a survival advantage versus the normal
neighboring cells. As a consequence, cells surrounding tumors are
eliminated and engulfed by macrophages. We propose a novel
scenario in which circulating cells facing a tumor can reproduce these
cellular interactions. In vitro cultured macrophages from murine bone
marrow were used to investigate this hypothesis. M1 macrophages in
tumoral medium upregulated markers of a suboptimal condition,
such as Sparc and TyrRS, and undergo apoptosis. However, M2
macrophages display higher Myc expression levels and proliferate at
the expense of M1. Resulting M1 apoptotic debris is engulfed by M2
in a Sparc- and TyrRS-dependent manner. These findings suggest
that tumor-dependent macrophage elimination could deplete immune
response against tumors. This possibility could be relevant for
macrophage based anti-tumoral strategies.
KW - Adenolinfoma
KW - Macrófagos
KW - Apoptosis
KW - Biología celular
LA - eng
ER -