TY - JOUR A1 - Muniesa Ferrero, Carlos Alberto AU - González-Freire, Marta AU - Santiago Dorrego, Catalina AU - Lao, José I. AU - Buxens, Amaya AU - Rubio, Juan Carlos AU - Martín, Miguel Ángel AU - Arenas, Joaquín AU - Gómez Gallego, Félix AU - Lucía Mulas, Alejandro T1 - World-class performance in lightweight rowing: is it genetically influenced? A comparison with cyclists, runners and non-athletes Y1 - 2010 SN - 14730480 UR - http://hdl.handle.net/11268/928 AB - In this study, genotype frequencies of several polymorphisms that are candidates to influence sports performance (ie, ACTN3 R577X, ACE ID, PPARGC1A Gly482Ser, AMPD1 C34T, CKMM 985bp/1170bp and GDF8 (myostatin) K153R) were compared in 123 nonathletic controls, 50 professional cyclists, 52 Olympic-class runners and 39 world-class rowers (medallists in world championships, lightweight category). Significant differences in genotype distributions among the groups were not found except for the ACE gene, that is, lower (p<0.05) proportion of II in rowers (10.3%) than in the total subject population (22.3%). In summary, sports performance is likely polygenic with the combined effect of hundreds of genetic variants, one possibly being the ACE ID polymorphism (at least in the sports studied here), but many others remain to be identified. KW - Genética humana LA - eng ER -