TY - JOUR 
A1 - Rodríguez Sánchez, Elena
AU - Navarro García, José Alberto
AU - Aceves Ripoll, Jennifer
AU - Álvarez Llamas, Gloria
AU - Segura, Julián
AU - Barderas, María G.
AU - Ruilope Urioste, Luis Miguel
AU - Ruiz Hurtado, Gema
T1 - Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients

Y1 - 2019
SN - 0211-6995

UR - http://hdl.handle.net/11268/8555
AB - Background and objective: Matrix metalloproteinases (MMPs)are involved in deleterious tissue remodelling associated with target organ damage in renal disease. The aim of this study was to study the association between renal dysfunction and activity of the inflammatory metalloproteinase MMP-9 in hypertensive patients with mild-moderate chronic kidney disease (CKD). Material and methods: Plasmatic active MMP-9, total MMP-9, tissue inhibitor of MMP-9 (TIMP-1), MMP-9/TIMP-1 ratio and MMP-9-TIMP-1 interaction were analysed in 37 hypertensive patients distributed by estimated glomerular filtration rate (eGFR)in 3 groups: >90, 90–60 and 60–30 mL/min/1.73 m2. Results: Total MMP-9 was not different as eGFR declines. TIMP-1 was significantly increased in hypertensive patients with eGFR 60–30 mL/min/1.73 m2 (p < 0.01 vs. >90 mL/min/1.73 m2). This relates to the significant decrease in the interaction between MMP-9-TIMP-1 observed in patients with eGFR 60–30 mL/min/1.73 m2 (p < 0.01 vs. >90 mL/min/1.73 m2). Despite the systemic elevation of TIMP-1, active MMP-9 was significantly increased in hypertensive patients with eGFR 60–30 mL/min/1.73 m2 (p < 0.05 and p < 0.01 vs. >90 and 90–60 mL/min/1.73 m2, respectively). TIMP-1, active MMP-9 and MMP-9-TIMP-1 interaction significantly correlate with the decline in renal function, which was not observed with total MMP-9. Conclusions: The progression of CKD, even in stages where the decline of renal function is still moderate, is associated with an increase in MMP-9 activity, which could be considered as a potential therapeutic target.
KW - Hipertensión
KW - Aparato circulatorio
KW - Proteínas
KW - Sistema cardiovascular
KW - Enfermedad cardiovascular
KW - Proteína
LA - eng
ER -