TY - JOUR 
A1 - Rubia Ortí, José Enrique de la
AU - Prado Gascó, Vicente Javier
AU - Sancho Castillo, Sandra
AU - Julián Rochina, Mariano
AU - Romero Gómez, Francisco Javier
AU - García Pardo, María Pilar
T1 - Cortisol and IgA are Involved in the Progression of Alzheimer’s Disease. A Pilot Study
Y1 - 2019
SN - 0272-4340

UR - http://hdl.handle.net/11268/8545
AB - It is known that stress and immune systems are related with Alzheimer’s disease (AD). However, the relationship of both systems in the progression of disease is not clearly demonstrated. Hair cortisol and salivary immunoglobulin A (IgA) were quantified in 49 patients with mild, moderate, and severe AD. A significant change was seen in both molecules as AD progressed from mild to moderate and severe. Low levels of cortisol were observed in mild AD patients compared with moderate and severe. However, IgA showed a contrary pattern. High levels were observed in mild AD patientes but low in moderate and severe AD subjects. The secretion of cortisol and IgA seems to be very different at the start compared with posterior development of AD suggesting that neuroinflammation can be involved. Both molecules could be used as possible therapeutical tools.
KW - Enfermedad de Alzheimer
KW - Estrés
KW - Enfermedad del sistema nervioso
KW - Estrés mental
LA - eng
ER -