TY - GEN 
A1 - Martínez Sellés Oliveria Soares, Manuel
AU - Martínez, Esther
AU - Cortés, Marcelino
AU - Prieto Castillejo, Raquel
AU - Gallego Parra, Laura
AU - Fernández-Avilés, Francisco
T1 - Determinants of long-term survival in patients hospitalized for heart failure
Y1 - 2010
UR - http://hdl.handle.net/11268/813
AB - Background and Objectives: Methods: Results: Conclusion: Current models used to stratify patients with heart failure are complex, difficult to use, and limited by short follow-up and patient selection. Our aim was to determine predictors of long-term survival in patients hospitalized for heart failure and to develop a simple mortality risk score to estimate long-term mortality.We prospectively followed up, during 10 years after hospitalization, 701 patients with confirmed heart failure from the HOLA (Heart failure: Observation of Local Admissions) registry.Mean age was 72.4 +/- 11.7 years; 45% were men. During follow-up, 465 patients died and 5 underwent heart transplantation. A total of 231 patients (33%) were alive and transplant-free at the end of follow-up (5.2 +/- 4.2 years). Median survival was 3.2 years. Multivariate analysis showed that six variables (age, previous renal disease, previous stroke, chronic obstructive pulmonary disease, left ventricular ejection fraction and aortic stenosis) were independent predictors of shorter survival time. By dichotomizing these variables, we obtained six factors with similar predictive values (hazard ratio between 1.5 and 2.0). A risk score for mortality was developed using these predictors by assigning 1 point to each and adding the total for each patient. Median survival for patients with 0, 1, 2, and 3 or more points were 6.5, 5.5, 3.3, and 1.7 years, respectively. One-year mortality rates were 15, 20, 28, and 49%, respectively.The prognosis of patients hospitalized with heart failure is highly variable. A simple risk score, based on six variables readily obtainable on admission can effectively stratify patients according to their predicted mortality.
KW - Health Status Indicators*
KW - Heart Failure/*Mortality
KW - Hospitalization/*Statistics & Numerical Data
KW - Survivors/*Statistics & Numerical Data
KW - Aortic Valve Stenosis/Mortality
KW - Female
KW - Follow-Up Studies
KW - Heart Failure/Physiopathology
KW - Heart Failure/Ultrasonography
KW - Humans
KW - Kaplan-Meier Estimate
KW - Kidney Diseases/Mortality
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive/Mortality
KW - Registries
KW - Risk Assessment
KW - Risk Factors
KW - Stroke/Mortality
KW - Stroke Volume
KW - Time Factors
KW - Ventricular Function, Left
KW - Enfermedad cardiovascular
KW - Análisis cuantitativo
LA - eng
ER -