TY - JOUR 
A1 - Llaó, Isaac
AU - Formiga, Francesc
AU - Ariza Solé, Albert
AU - Cruzado, Josep M.
AU - Sanchís, Juan
AU - Rama, Inés
AU - Martínez Sellés Oliveria Soares, Manuel
AU - Garay, Alberto
AU - Guerrero, Carme
AU - Díez Villanueva, Pablo
AU - Et al.
T1 - Frequency of Renal Dysfunction and Frailty in Patients ≥ 80 Years of Age With Acute Coronary Syndromes
Y1 - 2019
SN - 0002-9149

UR - http://hdl.handle.net/11268/7710
AB - While a significant association between renal function and outcomes in patients with acute coronary syndromes (ACS) has been consistently described, little information exists about the magnitude of this association in patients at older ages. No study assessed the prognostic role of renal function according to frailty in patients with ACS. The LONGEVO-SCA registry included unselected ACS patients aged≥80 years. Frailty was asessesed by the FRAIL scale, and baseline creatinine clearance was calculated by the Cockroff-Gault formula. We evaluated the impact of renal function on mortality or readmission at 6-months according to frailty status by the Cox regression method. A total of 473 patients were assessed, with a mean age of 84.2 years. The distribution of patients across estimated glomerular filtration rate (eGFR) subgroups was as follows: a) <30 ml/min: n=76 (16.1%); b) 30-44 ml/min: n=147 (31.1%); c) 45-60 ml/min: n=136 (28.8%); and d)> 60 ml/min: n=114 (24.1%). Patients with lower eGFR values were older, had a higher proportion of comorbidities and other geriatric syndromes (p=0.001) and underwent less often an invasive management during admission (p<0.001). The incidence of mortality or readmission at 6 months progressively increased across renal function subgroups (p=0.001). After adjusting for potential confounders, this association became non significant (p=0.802). The association between eGFR and outcomes was only significant in patients without frailty (p=0.001). In conclusion, most patients aged≥80 years with NSTEACS had renal function impairment at admission. The association between renal function and outcomes was different according to frailty status.
KW - Riñones
KW - Enfermedades
KW - Mortalidad
KW - Enfermedad
KW - Mortalidad
LA - eng
ER -