TY - JOUR 
A1 - Gómez Gallego, Félix
AU - Ruiz, Jonatan R.
AU - Buxens, Amaya
AU - Altmäe, Signe
AU - Artieda, Marta
AU - Santiago Dorrego, Catalina
AU - González-Freire, Marta
AU - Verde Rello, Zoraida
AU - Arteta, David
AU - Martínez Amat, Antonio
AU - Tejedor, Diego
AU - Lao, José I.
AU - Arenas, Joaquín
AU - Lucía Mulas, Alejandro
T1 - Are elite endurance athletes genetically predisposed to lower disease risk?
Y1 - 2010
SN - 15312267
UR - http://hdl.handle.net/11268/765
AB - We compared a polygenic profile that combined 33 disease risk-related mutations and polymorphisms among nonathletic healthy control subjects and elite endurance athletes. The study sample comprised 100 healthy Spanish male nonathletic (sedentary) control subjects and 100 male elite endurance athletes. We analyzed 33 disease risk-related mutations and polymorphisms. We computed a health-related total genotype score (TGS, 0-100) from the accumulated combination of the 33 variants. We did not observe significant differences in genotype or allele distributions among groups, except for the rs4994 polymorphism (P < 0.001). The computed health-related TGS was similar among groups (23.8 +/- 1.0 vs. 24.2 +/- 0.8 in control subjects and athletes, respectively; P = 0.553). Similar results were obtained when computing specific TGSs for each main disease category (cardiovascular disease and cancer). We observed no evidence that male elite endurance athletes are genetically predisposed to have lower disease risk than matched nonathletic control subjects.
KW - Enfermedad
KW - Medicina deportiva
KW - Atleta
LA - eng
ER -