TY - JOUR 
A1 - Clemente Suárez, Vicente Javier
AU - Mielgo Ayuso, Juan
AU - Quiles Morales, José Luís
AU - Varela López, Alfonso
AU - Aranda Ramírez, Pilar
T1 - Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity
Y1 - 2017
SN - 2498-602X
UR - http://hdl.handle.net/11268/7628
AB - This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0.05). The mean corpuscular hemoglobin and lymphocytes concentrations were significantly higher in the VECG than in the other two groups (p < 0.05). Similarly, VEAG presented a significantly higher vit E blood concentration than VECG and CG (p < 0.05), and VECG than CG (p < 0.05). Finally, we found a significantly positive correlation between trolox equivalent antioxidant capacity (TEAC) and red blood cells concentration (r = 0.374) and a significantly inverse correlation between TEAC and blood lactate concentration (r = −0.365). Our findings suggest that acute vit E megadoses could protect against transitory sport anemia symptoms and increase the white blood cell count in comparison with the chronic dose and control groups after an ultraendurance probe.
KW - Antioxidantes
KW - Hematología
KW - Vitamina E
KW - Vitamina
KW - Investigación
KW - Desarrollo fisiológico
LA - eng
ER -