TY - JOUR 
A1 - Ramírez Jiménez, Miguel
AU - Fernández Elías, Valentín Emilio
AU - Morales Palomo, Félix
AU - Ortega Fonseca, Juan Fernando
AU - Mora Rodríguez, Ricardo
T1 - Intense aerobic exercise lowers blood pressure in individuals with metabolic syndrome taking antihypertensive medicine
Y1 - 2018
SN - 359-5237
UR - http://hdl.handle.net/11268/7542
AB - OBJECTIVE:
There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise.

PARTICIPANTS AND METHODS:
Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order. One trial was conducted after taking their habitual dose of ARB (ARB MED trial) and another after 48 h of placebo medicine (i.e. dextrose; PLAC trial).

RESULTS:
After placebo medication, brachial systolic blood pressure increased by 5.5 mmHg [P=0.009; effect size (ES)=0.476] and diastolic by 2.5 mmHg (P=0.030; ES=0.373). Exercise reduced systolic and diastolic blood pressures to the same extent in ARB MED and PLAC trials (7 and 8 mmHg, respectively, for systolic and 5 and 4 mmHg, respectively, for diastolic, all P<0.05). Pulsatile measures of arterial stiffness did not reveal an interaction effect between exercise and medication. However, postocclusion reactive hyperemia increased after exercise only in the ARB MED trial (361±169 to 449±240% from baseline; P=0.033; ES=0.429).

CONCLUSION:
ARBs and a bout of intense exercise each have an independent effect on lowering blood pressure in hypertensive individuals, and these effects are additive.
KW - Presión sanguínea
KW - Ejercicio físico
KW - Sistema cardiovascular
KW - Deporte
LA - eng
ER -