TY - JOUR 
A1 - Fiuza Luces, María del Carmen
AU - Díez Bermejo, Jorge
AU - Fernández de la Torre, Miguel
AU - Rodríguez Romo, Gabriel
AU - Sanz Ayan, Paz
AU - Delmiro, Aitor
AU - Munguía-Izquierdo, Diego
AU - Rodríguez Gómez, Irene
AU - Lucía Mulas, Alejandro
AU - Morán, María
T1 - Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders
Y1 - 2018
SN - 0195-9131
UR - http://hdl.handle.net/11268/7308
AB - Purpose
We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease.

Methods
Several end points were assessed in 12 patients (19–59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points).

Results
The program was safe, with patients’ adherence being 94% ± 5%. A significant time effect was found for virtually all main end points (P ≤ 0.004), indicating a training improvement. Similar findings (P ≤ 0.003) were found for activities of daily living tests, total/trunk/leg lean mass, total fat mass, femoral fracture risk, and general health perception. No differences were found for blood myokines, except for an acute exertional increase in interleukin 8 at posttraining/detraining (P = 0.002) and in fatty acid binding protein 3 at detraining (P = 0.002).

Conclusions
An intervention including novel exercises for mitochondrial disease patients (e.g., inspiratory muscle training) produced benefits in numerous indicators of physical capacity and induced a previously unreported shift toward a healthier body composition phenotype.
KW - Mitochondrial disorders
KW - Innovative exercise program
KW - Ejercicio físico
KW - Calidad de vida
KW - Beneficios complementarios
KW - Deporte
LA - eng
ER -