TY - JOUR 
A1 - Baldán Martín, Montserrat
AU - López, Juan Antonio
AU - Corbacho Alonso, Nerea
AU - Martínez, Paula J.
AU - Rodríguez Sánchez, Elena
AU - Mouriño Álvarez, Laura
AU - Sastre Oliva, Tamara
AU - Martín Rojas, Tatiana
AU - Ruilope Urioste, Luis Miguel
AU - Barderas, María G.
AU - Et al.
T1 - Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
Y1 - 2018
SN - 2045-2322
UR - http://hdl.handle.net/11268/7265
AB - The evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk®), estimates CV risk throughout a subjects’ lifetime, allowing those. A more aggressive and earlier intervention to be identified and offered protection from the consequences of CV and renal disease. The search for molecular profiles in young people that allow a correct stratification of CV risk would be of great interest to adopt preventive therapeutic measures in individuals at high CV risk. To improve the selection of subjects susceptible to intervention with aged between 30–50 years, we have employed a multiple proteomic strategy to search for new markers of early CV disease or reported CV events and to evaluate their relationship with Lifetime Risk. Blood samples from 71 patients were classified into 3 groups according to their CV risk (healthy, with CV risk factors and with a previously reported CV event subjects) and they were analyzed using a high through quantitative proteomics approach. This strategy allowed three different proteomic signatures to be defined, two of which were related to CV stratification and the third one involved markers of organ damage.
KW - Cardiopatía coronaria
KW - Medicina preventiva
KW - Enfermedad cardiovascular
KW - Medicina preventiva
LA - eng
ER -