TY - JOUR 
A1 - Varo, Rosauro
AU - Sitoe, Antonio
AU - Cossa, Anelsio
AU - Ordi, Jaume
AU - Rozman, Maria
AU - Bassat, Quique
T1 - Leukoerythroblastosis in a Young Child with Severe Malaria and Superimposed Gram Negative Infection
Y1 - 2017
SN - 0142-6338

UR - http://hdl.handle.net/11268/7058
AB - Background:
Leukoerythroblastosis, a non-specific and often short-lasting response of the bone marrow to different diseases such as malignancies or infections, is characterized by the presence in the peripheral blood of immature red and white cells.

Methods:
We present a case of leukoerythoblastosis occurring in a 24 months old Mozambican girl, in the context of a severe malaria episode and an associated urinary tract infection. Peripheral blood smear was used for diagnosis of malaria and leukoerythroblastosis. Enterobacter cloacae isolation and antibiotic susceptibility testing were performed by conventional microbiology.

Results:
Peripheral blood smear was positive for Plasmodium falciparum and showed a leukoerythroblastosis with red cell anisopoikilocytosis and left shifted neutrophils. Urine culture confirmed the presence of a multi-resistant E. cloacae. Treatment of underlying conditions resolved the leukoerythroblastic reaction.

Conclusions:
Leukoerythroblastosis may be related to different infectious diseases and may also appear in the context of severe malaria. Bacterial superinfection needs to be investigated.
KW - Paludismo
KW - Aparato urinario
KW - Malaria
KW - Enfermedad transmisible
LA - eng
ER -