TY - JOUR 
A1 - Sánchez-Quintana, Damián
AU - López Mínguez, José Ramón
AU - Pizarro, Gonzalo
AU - Murillo Haba, Margarita
AU - Cabrera Rodríguez, José Ángel
T1 - Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation
Y1 - 2012
SN - 1573403X
UR - http://hdl.handle.net/11268/6214
AB - The definition of atrial fibrillation (AF) as a functional electrical disorder does not reflect the significant underlying structural abnormalities. Atrial and Pulmonary Vein (PV) muscle sleeve microstructural remodeling is present, and establishes a vulnerable substrate for AF maintenance. In spite of an incomplete understanding of the anatomo-functional basis for AF, current evidence demonstrates that this arrhythmia usually requires a trigger for initiation and a vulnerable electrophysiological and/or anatomical substrate for maintenance. It is still unclear whether the trigger mechanisms include focal enhanced automaticity, triggered activity and/or micro re-entry from myocardial tissue. Initiation of AF can be favored by both parasympathetic and sympathetic stimulation, which also seem to play a role in maintaining AF. Finally, evolving clinical evidence demonstrates that inflammation is associated with new-onset and recurrent AF through a mechanism that possibly involves cellular degeneration, apoptosis, and subsequent atrial fibrosis. © 2012 Bentham Science Publishers.
KW - Cardiología
KW - Vasos sanguíneos
KW - Aparato respiratorio
KW - Sistema cardiovascular
KW - Aparato respiratorio
LA - eng
ER -