TY - JOUR 
A1 - Domínguez Rodríguez, Alberto 
AU - Abreu González, Pedro
AU - Reiter, Russel J.
T1 - Melatonin for cardioprotection in ST elevation myocardial infarction: Are we ready for the challenge?
Y1 - 2016
SN - 13556037

UR - http://hdl.handle.net/11268/6151
AB - Melatonin, an endocrine product of the pineal gland, is formed predominantly during the nighttime. Light has an inhibitory effect on pineal melatonin secretion. Pineal melatonin release is synchronised by this daily light-dark cycle via a multisynaptic pathway between the eyes and the pineal gland. Light stimulates the retina to modulate the activity of the suprachiasmatic nucleus, the master biological clock.1 The suprachiasmatic nucleus controls pineal melatonin synthesis and the concentrations of melatonin in the sera of healthy subjects, which reach values of 10−10 to 10−9 mol/L during the night, with much lower concentrations being present during the day. Many publications have shown that melatonin has an important role in a variety of cardiovascular pathophysiologic processes: the indoleamine has anti-inflammatory, antioxidant, antihypertensive, antithrombotic and antilipaemic properties.
KW - Melatonin
KW - Cardiología
KW - Sistema cardiovascular
KW - Tratamiento médico
LA - eng
ER -