TY - JOUR 
A1 - Ruiz, Jonatan R.
AU - Eynon, Nir
AU - Meckel, Yoav
AU - Fiuza Luces, María del Carmen
AU - Santiago Dorrego, Catalina
AU - Gómez Gallego, Félix
AU - Oliveira, José
AU - Lucía Mulas, Alejandro
T1 - GNB3 C825T Polymorphism and elite athletic status: A replication study with two ethnic groups
Y1 - 2011
SN - 14393964
UR - http://hdl.handle.net/11268/614
AB - We aimed to replicate the original findings by Eynon et al. showing an association between the T allele of the GNB3 C825T polymorphism and elite endurance athletic status, in larger cohorts and in other ethnicities. We compared allelic and genotypic frequencies of the GNB3 C825T polymorphism among non-athletic controls (N=340), elite endurance athletes (N=174), and power athletes (N=134). The population sample included participants from 2 different ethnic/geographic backgrounds (Israel and Spain). We observed no significant differences in genotypic and allelic frequencies between countries or groups (all P>0.1). The odds ratio (OR) of being an endurance athlete if the subject had a T allele was 0.841 (95%CI: 0.638-1.110) compared to the control group and 1.047 (95% CI: 0.751-1.461) compared to the power group. Our findings support the need to corroborate genotype: phenotype associations in the field of sports genetics with the largest possible population samples, including populations of different ethnic backgrounds.
KW - Athletes*
KW - Polymorphism, Single Nucleotide*
KW - Ethnic Groups/*Genetics
KW - Heterotrimeric Gtp-Binding Proteins/*Genetics
KW - Athletic Performance
KW - Cohort Studies
KW - Female
KW - Genetic Association Studies
KW - Genetic Testing
KW - Genetics, Population
KW - Genotype
KW - Humans
KW - Israel
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Phenotype
KW - Reproducibility of Results
KW - Spain
KW - Genética humana
LA - eng
ER -