TY - JOUR 
A1 - Senni, M.
AU - McMurray, John J. V.
AU - Wachter, R.
AU - McIntyre, H. F.
AU - Reyes, A.
AU - Majercak, I.
AU - Andreka, P.
AU - Shehova-Yankova, Nina
AU - Anand, I.
AU - Yilmaz, M. B.
AU - Gogia, H.
AU - Martínez Sellés Oliveria Soares, Manuel
AU - Fischer, S.
AU - Zilahi, Z.
AU - Cosmi, F.
AU - Gelev, V.
AU - Galve Basilio, Enrique
AU - Gómez Doblas, J. J.
AU - Nociar, J.
AU - Radomska, M.
AU - Sokolova, B.
AU - Volterrani, M.
AU - Sarkar, A.
AU - Reimund, B.
AU - Chen, F.
AU - Charney, A.
T1 - Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens
Y1 - 2016
SN - 13889842

UR - http://hdl.handle.net/11268/6090
AB - The aim is tassess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) preceded an 11-week, double-blind, randomization period [100 mg twice daily for 2 weeks followed by 200 mg twice daily (‘condensed’ regimen) vs. 50 mg twice daily for 2 weeks, 100 mg twice daily for 3 weeks, followed by 200 mg twice daily (‘conservative’ regimen)]. Patients were stratified by pre-study dose of angiotensin-converting enzyme inhibitor/angiotensin-receptor blocker (ACEI/ARB; low-dose stratum included ACEI/ARB-naïve patients). Of 540 patients entering run-in, 498 (92%) were randomized and 429 (86.1% of randomized) completed the study. Pre-defined tolerability criteria were hypotension, renal dysfunction and hyperkalaemia; and adjudicated angioedema, which occurred in (‘condensed’ vs. ‘conservative’) 9.7% vs. 8.4% (P = 0.570), 7.3% vs. 7.6% (P = 0.990), 7.7% vs. 4.4% (P = 0.114), and 0.0% vs. 0.8% of patients, respectively. Corresponding proportions for pre-defined systolic blood pressure <95 mmHg, serum potassium >5.5 mmol/L, and serum creatinine >3.0 mg/dL were 8.9% vs. 5.2% (P = 0.102), 7.3% vs. 4.0% (P = 0.097), and 0.4% vs. 0%, respectively. In total, 378 (76%) patients achieved and maintained sacubitril/valsartan 200 mg twice daily without dose interruption/down-titration over 12 weeks (77.8% vs. 84.3% for ‘condensed’ vs. ‘conservative’; P = 0.078). Rates by ACEI/ARB pre-study dose stratification were 82.6% vs. 83.8% (P = 0.783) for high-dose/‘condensed’ vs. high-dose/‘conservative’ and 84.9% vs. 73.6% (P = 0.030) for low-dose/‘conservative’ vs. low-dose/‘condensed’. Initiation/uptitration of sacubitril/valsartan from 50 to 200 mg twice daily over 3 or 6 weeks had a tolerability profile in line with other HF treatments. More gradual initiation/uptitration maximized attainment of target dose in the low-dose ACEI/ARB group.
KW - Insuficiencia cardíaca
KW - Corazón - Enfermedades
KW - Enfermedad cardiovascular
LA - eng
ER -