TY - JOUR 
A1 - Hirsch, June C.
AU - Agassandian, Christopher
AU - Merchán-Pérez, Ángel
AU - Ben-Ari, Yézéquiel
AU - DeFelipe, Javier
AU - Esclapez, Monique
AU - Bernard, Christopher
T1 - Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy
Y1 - 1999
SN - 10976256
UR - http://hdl.handle.net/11268/6003
AB - Because GABA (gamma-aminobutyric acid) receptor-mediated inhibition controls the excitability of principal neurons in the brain, deficits in GABAergic inhibition have long been favored to explain seizures. In an experimental model of temporal lobe epilepsy, we have identified a deficit of inhibition in presynaptic GABAergic terminals characterized by decreased GABA quantal activity associated with reduced synaptic vesicle density. This decrease in vesicle number primarily seems to affect the reserve pool, rather than the docked or the readily releasable pool.
KW - Neurociencias
KW - Epilepsia
KW - Neurología
KW - Enfermedad del sistema nervioso
LA - eng
ER -