TY - JOUR 
A1 - Palao Suay, Raquel
AU - Rodríguañez, Laura
AU - Aguilar de Armas, María Rosa
AU - Sánchez Rodríguez, Carolina
AU - Parra Ruiz, F. J.
AU - Fernández Gutiérrez, M.
AU - Parra, J.
AU - Riestra Ayora, Juan Ignacio
AU - Sanz Fernández, Ricardo
AU - Román, J. S.
T1 - Mitochondrially Targeted Nanoparticles Based on α-TOS for the Selective Cancer Treatment
Y1 - 2016
SN - 1616-5187
UR - http://hdl.handle.net/11268/5935
AB - The aim of this work is the preparation of an active nanovehicle for the effective administration
of α-tocopheryl succinate (α-TOS). α-TOS is loaded in the core of nanoparticles (NPs) based
on amphiphilic pseudo-block copolymers of N-vinyl pyrrolidone and a methacrylic derivative of
α-TOS. These well-defi ned spherical NPs have sizes below 165 nm and high encapsulation effi -
ciencies. In vitro activity of NPs is tested in hypopharynx squamous carcinoma (FaDu) cells and
nonmalignant epithelial cells, demonstrating that the presence of additional α-TOS signifi cantly
enhances its antiproliferative activity; however, a range of selective concentrations is observed.
These NPs induce apoptosis of FaDu cells by activating the mitochondria death pathway (via
caspase-9). Both loaded and unloaded NPs act via complex II and produce high levels of reactive
oxygen species that trigger apoptosis. Additionally, these
NPs effectively suppress the vascular endothelial growth factor
(VEGF) expression of human umbilical vein endothelial cells
(HUVECs). These results open the possibility to use this promising
nanoformulation as an α-TOS delivery system for the
effective cancer treatment, effectively resolving the current
limitations of free α-TOS administration.
KW - Polímeros
KW - Salud
KW - Polímero
KW - Salud
LA - eng
ER -