TY - JOUR 
A1 - López Chicharro, José
AU - López-Calderón, Asunción
AU - Hoyos, J.
AU - Martín Velasco, Ana Isabel
AU - Villa Vicente, José Gerardo
AU - Villanúa, María de los Ángeles
AU - Lucía Mulas, Alejandro
T1 - Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3  
Y1 - 2001
SN - 03063674

UR - http://hdl.handle.net/11268/5754
AB - The aim of this study is to determine whether consecutive bouts of intense endurance exercise over a three week period alters serum concentrations of insulin-like growth factor I (IGF-I) and/or its binding proteins. Seventeen professional cyclists (mean (SEM) VO2MAX, 74.7 (2.1) ml/kg/min; age, 27 (1) years) competing in a three week tour race were selected as subjects. Blood samples were collected at each of the following time points: t0 (control, before the start of competition), t1 (end of first week), and t3 (end of third week). Serum levels of both total and free IGF-I and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3) were measured in each of the samples. Cortisol levels were measured in nine subjects. A significant (p<0.01) increase was found in total IGF-I and IGFBP-1 at both t1 and t3 compared with t0 (IGF-I: 110.9 (17.7), 186.8 (12.0), 196.9 (14.7) ng/ml at t0, t1, and t3 respectively; IGFBP-1: 54.6 (6.6), 80.6 (8.0), and 89.2 (7.9) ng/ml at t0, t1, and t3 respectively). A significant (p<0.01) decrease was noted in free IGF-I at t3 compared with both t0 and t1 (t0: 0.9 (0.1) ng/ml; t1: 0.9 (0.1) ng/ml; t3: 0.7 (0.1) ng/ml); in contrast, IGFBP-3 levels remained stable throughout the race. It would appear that the increase in circulating levels of both IGF-I and its binding protein IGFBP-1 is a short term (one week) endocrine adaptation to endurance exercise. After three weeks of training, total IGF-I and IGFBP-1 remained stable, whereas free IGF-I fell below starting levels.
KW - Proteínas
KW - Insulina
KW - Medicina deportiva
KW - Medicina deportiva
KW - Proteína
LA - eng
ER -