TY - JOUR 
A1 - Pérez Ruiz, Margarita
AU - Maté-Muñoz, José Luis
AU - Foster, Carl
AU - Rubio, Juan Carlos
AU - Andreu, Antoni L.
AU - Martín, Miguel Ángel
AU - Arenas, Joaquín
AU - Lucía Mulas, Alejandro
T1 - Exercise capacity in a child with McArdle disease
Y1 - 2007
SN - 08830738

UR - http://hdl.handle.net/11268/5559
AB - We report the exercise capacity of an 8-year-old boy with clinical, histological, biochemical, and genetic evidence of McArdle disease. The patient presented with severe myalgia, proteinuria, hematuria, pyrexia, and elevated creatine kinase after swimming. After pre-exercise ingestion of sucrose, he performed treadmill exercise to symptom limitation. His peak oxygen uptake (18.8 mL/kg/min) and ventilatory threshold (16.0 mL/kg/min) were reduced by 40% and 20% compared with healthy age-matched and gender-matched controls. The results suggest that exercise capacity is reduced early in life in patients with McArdle disease and suggest the need for prophylactic exercise training (following pre-exercise feeding to prevent rhabdomyolysis) to minimize deconditioning.
KW - Enfermedades - McArdle
KW - Metabolismo
KW - Deporte
LA - eng
ER -