TY - JOUR 
A1 - Eynon, Nir
AU - Ruiz, Jonatan R.
AU - Meckel, Yoav
AU - Morán, María
AU - Lucía Mulas, Alejandro
T1 - Mitochondrial biogenesis related endurance genotype score and sports performance in athletes
Y1 - 2011
SN - 18728278
UR - http://hdl.handle.net/11268/549
AB - We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
KW - Polymorphism, Genetic*
KW - Athletic Performance/*Physiology
KW - European Continental Ancestry Group/*Genetics
KW - Mitochondria/*Genetics
KW - Physical Endurance/*Genetics
KW - Transcription Factors/*Genetics
KW - Athletes
KW - Female
KW - Gene Frequency
KW - Genotype
KW - Heat-Shock Proteins/Genetics
KW - Humans
KW - Israel
KW - Male
KW - Middle Aged
KW - Mitochondria/Metabolism
KW - Ppar Delta/Genetics
KW - Physical Endurance/Physiology
KW - Sports
KW - Transcription Factors/Metabolism
KW - Genética humana
LA - eng
ER -