TY - JOUR 
A1 - He, Zi-Hong
AU - Hu, Yang
AU - Feng, Lianshi
AU - Bao, Dapeng
AU - Xi, Yi
AU - Wen, Li
AU - Lucía Mulas, Alejandro
T1 - Relationship between TFAM gene polymorphisms and endurance capacity in response to training
Y1 - 2007
SN - 01724622

UR - http://hdl.handle.net/11268/5453
AB - The aim of this study was to explore whether polymorphisms in mitochondrial transcription factor A ( TFAM) gene are associated with endurance capacity in a pretraining state (baseline) and/or in response to a supervised 18-wk endurance training (changes) in 102 young Chinese males (nonathletes). Phenotypes measured were running economy (RE) and V.O↓2max. Genomic DNA was extracted from white blood cells and the genotypes were analyzed by PCR-RFLP in single nucleotide polymorphisms (SNP) rs1937, rs2306604 and rs1049432. Genotype distributions were in Hardy-Weinberg equilibrium at three loci (p > 0.05). When the three polymorphisms were considered together, three haplotypes were estimated, i.e., G (rs1937)-A (rs2306604)-G (rs1049432) (49 %), G (rs1937)-G (rs2306604)-G (rs1049432) (33 %) and C (rs1937)-G (rs2306604)-T (rs1049432) (18 %). SNPrs1937 and rs1049432 achieved near complete linkage disequilibrium (LD) (D' = 1 and r↑2 = 0.903). We found no significant differences in baseline levels of V.O↓2max and RE between TFAM genotypes or haplotypes. Similarly, we found no differences for the training-induced changes of both variables. It was concluded that the three polymorphisms in TFAM gene rs1937, rs2306604 and rs1049432 do not predict endurance capacity/trainability, at least in Chinese males.
KW - Fisiología del deporte
KW - Genética humana
KW - Genética humana
LA - eng
ER -