TY - JOUR 
A1 - Pareja Galeano, Helios
AU - Sanchís-Gomar, Fabián
AU - Pérez, Laura M.
AU - Emanuele, Enzo
AU - Lucía Mulas, Alejandro
AU - González Gálvez, Beatriz
AU - Gallardo, María Esther
T1 - iPSCs-based anti-aging therapies: Recent discoveries and future challenges
Y1 - 2016
SN - 1568-1637
UR - http://hdl.handle.net/11268/5009
AB - The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition.
KW - Geriatría
KW - Gerontología
KW - Salud
LA - eng
ER -