TY - JOUR 
A1 - Pérez, Laura M.
AU - Pareja Galeano, Helios
AU - Sanchís-Gomar, Fabián
AU - Emanuele, Enzo
AU - Lucía Mulas, Alejandro
AU - González Gálvez, Beatriz
T1 - 'Adipaging': Aging and obesity share biological hallmarks related to a dysfunctional adipose tissue
Y1 - 2016
SN - 14697793

UR - http://hdl.handle.net/11268/5007
AB - The increasing aging of our societies is accompanied by a pandemic of obesity and related cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is increasingly recognized as an important hallmark of the aging process which in turn contributes to metabolic alterations, multi-organ damage, and a systemic pro-inflammatory state ('inflammaging'). On the other hand, obesity, the paradigm of adipose tissue dysfunction, shares numerous biological similarities with the normal aging process such as chronic inflammation and multi-system alterations. Accordingly, understanding the interplay between accelerated aging related to obesity and adipose tissue dysfunction is critical to gain insight into the aging process in general as well as into the pathophysiology of obesity and other related conditions. Here we postulate the concept of 'adipaging' to illustrate the common links between aging and obesity and the fact that, to a great extent, obese adults are prematurely aged individuals.
KW - Conducta alimentaria
KW - Obesidad
KW - Obesidad
LA - eng
ER -