TY - JOUR A1 - Garatachea, Nuria AU - Marín, Pedro J. AU - Santos-Lozano, Alejandro AU - Sanchís-Gomar, Fabián AU - Emanuele, Enzo AU - Lucía Mulas, Alejandro T1 - The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis Y1 - 2015 SN - 15491684 UR - http://hdl.handle.net/11268/4026 AB - The objective of this meta-analysis was to determine the association of the apolipoprotein E (ApoE) gene with exceptional longevity (EL) (i.e., reaching 100+ years) by identifying possible unequal distribution of alleles/genotypes in the common variants ε2, ε3, and ε4 among centenarians and younger population. The association of ApoE with EL was analyzed in a total of 2776 centenarians (cases) and 11,941 younger controls (from 13 case-control studies) using the chi-squared test with the Yates correction. We conducted combined and separate analyses for all ethnic groups studied in the literature (Caucasian and Asian). The present meta-analysis confirms that, besides its previously documented influence on Alzheimer's and cardiovascular disease risk, the ApoE gene is associated with the likelihood of reaching EL. KW - Envejecimiento KW - Genética KW - Ciencia KW - Envejecimiento KW - Genética humana LA - eng ER -