TY - JOUR 
A1 - Ruiz, Jonatan R.
AU - Gil Bea, Francisco
AU - Bustamante-Ara, Natalia
AU - Rodríguez Romo, Gabriel
AU - Fiuza Luces, María del Carmen
AU - Serra-Rexach, José A.
AU - Cedazo-Mínguez, Ángel
AU - Lucía Mulas, Alejandro
T1 - Resistance training does not have an effect on cognition or related serum biomarkers in nonagenarians: a randomized controlled trial
Y1 - 2015
SN - 01724622

UR - http://hdl.handle.net/11268/4025
AB - The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians. We also studied the effects of a 4-week training cessation ('detraining') period on our study variables. Participants were randomly allocated to a standard-care (control) or intervention (exercise) group [n=20 (16 women)/group]. The intervention focused on supervised, light-to-moderate-intensity aerobic and resistance exercises (mainly leg press), and included 3 weekly sessions. Cognitive status was determined by the mini-mental state examination and geriatric depression scale. We analysed proteins with reported relation with mechanisms behind cognition changes such as serum levels of angiotensin converting enzyme, amyloid-precursor protein, epidermal growth factor, brain-derived neural factor and tumor necrosis factor. No significant change (P>0.05) in any of the variables studied was found following the exercise intervention compared with the standard-care group. Similarly, no significant changes (P>0.05) were observed following the detraining period compared with the standard-care group.
KW - Physical activity
KW - Cognitive decline
KW - Cognitive function
KW - Mini-mental state examination
KW - Elderly
KW - Envejecimiento
KW - Ejercicio físico
KW - Salud
KW - Ciencia
KW - Envejecimiento
KW - Salud
LA - eng
ER -