TY - JOUR A1 - Palao Suay, Raquel AU - Aguilar de Armas, María Rosa AU - Parra Ruiz, F. J. AU - Fernández Gutiérrez, M. AU - Parra, J. AU - Sánchez Rodríguez, Carolina AU - Sanz Fernández, Ricardo AU - Rodrigáñez Riesco, Laura AU - Román, J. S. T1 - Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship Y1 - 2015 SN - 15257797 UR - http://hdl.handle.net/11268/4020 AB - α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring. KW - Vitaminas KW - Cáncer KW - Salud KW - Ciencias médicas KW - Cáncer KW - Vitamina LA - eng ER -