TY - JOUR 
A1 - Martínez Sellés Oliveria Soares, Manuel
AU - Díez Villanueva, Pablo
AU - Sánchez-Sendin, Domingo
AU - Carro Hevia, Amelia
AU - Gómez Doblas, J. J.
AU - García de la Villa, Bernardo
AU - Cornide, L.
AU - Alonso Tello, Albert
AU - Andión Ogando, Ramón
AU - Ripoll Vera, Tomás
AU - Arribas Jiménez, Antonio
AU - Carrillo, P.
AU - Rodríguez Pascual, Carlos
AU - Casares i Romeva, María
AU - Borras, X.
AU - Vázquez, Sandra
AU - López Palop, Ramón
T1 - Comorbidity and intervention in octogenarians with severe symptomatic aortic stenosis
Y1 - 2015
SN - 01675273
UR - http://hdl.handle.net/11268/4015
AB - Background
The benefit from intervention in elderly patients with symptomatic severe aortic stenosis (AS) and high comorbidity is unknown. Our aims were to establish the correlation between the Charlson comorbidity index and the prognosis of octogenarians with symptomatic sever AS and to identify patients who might not benefit from intervention.

Methods
We used the data from PEGASO (Pronóstico de la Estenosis Grave Aórtica Sintomática del Octogenario — Prognosis of symptomatic severe aortic stenosis in octogenarians), a prospective registry that included consecutively 928 patients aged ≥ 80 years with severe symptomatic AS.

Results
The mean Charlson comorbidity index was 3.0 ± 1.7, a total of 151 patients (16.3%) presented high comorbidity (index ≥ 5). Median survival was lower for patients with high comorbidity than for those without (16.7 ± 1.2 vs. 26.5 ± 0.6 months, p < 0.001). In patients without high comorbidity planned interventional management was clearly associated with prognosis (log rank p < 0.001), which was not the case in patients with high comorbidity (log rank p > 0.10). In multivariate analysis, the only variables that were independently associated with prognosis were planned medical management and Charlson index. Patients with high comorbidity presented non-cardiac death more frequently than those who had not (28.6% vs. 19.5%, p = 0.008).

Conclusions
One sixth of octogenarians with symptomatic severe AS have very high comorbidity (Charlson index ≥ 5). These patients have a poor prognosis in the short term and do not seem to benefit from interventional treatment.
KW - Aorta
KW - Estenosis
KW - Cardiología
KW - Acianos
KW - Sistema cardiovascular
KW - Anciano
LA - eng
ER -