TY - JOUR 
A1 - Fiuza Luces, María del Carmen
AU - Garatachea, Nuria
AU - Simpson, Richard J.
AU - Berger, Nathan A.
AU - Ramírez, Manuel
AU - Lucía Mulas, Alejandro
T1 - Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients
Y1 - 2015
SN - 10775552
UR - http://hdl.handle.net/11268/3970
AB - Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD
KW - Condición física
KW - Ejercicio físico
KW - Educación física
KW - Salud
LA - eng
ER -