TY - JOUR 
A1 - Chamorro-Viña, Carolina
AU - Ruiz, Jonatan R.
AU - Santana Sosa, Elena
AU - González Vicent, Marta
AU - Madero López, Luis
AU - Pérez Ruiz, Margarita
AU - Fleck, Steven J.
AU - Pérez Martínez, Antonio
AU - Ramírez, Manuel
AU - Lucía Mulas, Alejandro
T1 - Exercise during hematopoietic stem cell transplant hospitalization in children
Y1 - 2010
SN - 15300315
UR - http://hdl.handle.net/11268/384
AB - Purpose: Methods: Results: Conclusion: The purpose of this controlled trial was to assess the effect of an approximately 3-wk intrahospital exercise intervention performed during inpatient hospitalization for pediatric allogeneic hematopoietic stem cell transplant (HSCT) on (i) immune cell recovery and (ii) body composition.Immune (i.e., blood counts of leukocytes, monocytes, lymphocytes, and lymphocyte subpopulations) and anthropometric variables (i.e., body mass, body mass index, and estimated fat-free mass) were measured before and after (+15 and 30 d) HSCT. Seven children (5 boys and 2 girls; age (mean +/- SD) = 8 +/- 4 yr) with high-risk cancer performed an individualized training program (aerobic + resistance exercises) in their isolated hospital rooms. We also assessed a control group (n = 13; 9 boys and 4 girls; age = 7 +/- 3 yr) with similar medical conditions and following the same transplant protocol.In both groups, the dendritic cell count decreased from pre-HSCT to +15 d post-HSCT and thereafter (up to +30 d) remained stabile; however, the posttransplant decrease was more abrupt in the control group than that in the intervention group (-87% vs -63%, respectively, from pre-HSCT to +15 d). The rest of the immune cell parameters measured showed a similar response from pre-HSCT to post-HSCT in both groups. We found a significant effect of the interaction group x time for all anthropometric variables (weight, body mass index, body fat, and fat-free mass), indicating an increase over the hospitalization period only in the intervention group, for example, body mass increased from 32.9 +/- 18.7 kg pre-HSCT to 35.4 +/- 18.6 kg at +30 d in the intervention group versus a decrease from 30.2 +/- 16.6 to 29.3 +/- 6.3 kg in the control group.Our findings support the feasibility of exercise training interventions during hospitalization, including immunocompromised children.
KW - Medicina clínica
KW - Deporte
KW - Tratamiento médico
LA - eng
ER -