TY - JOUR 
A1 - Pinós, Tomás
AU - Fuku, Noriyuki
AU - Cámara, Yolanda
AU - Arai, Yasumichi
AU - Abe, Yukiko
AU - Rodríguez Romo, Gabriel
AU - Garatachea, Nuria
AU - Santos-Lozano, Alejandro
AU - Miro-Casas, Elisabet
AU - Ruiz-Meana, Marisol
AU - Otaegui, Imanol
AU - Murakami, Haruka
AU - Miyachi, Motohiko
AU - García-Dorado, David
AU - Hinohara, Kunihiko
AU - Andreu, Antoni L.
AU - Kimura, Akinori
AU - Hirose, Nobuyoshi
AU - Lucía Mulas, Alejandro
T1 - The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts
Y1 - 2014
UR - http://hdl.handle.net/11268/1947
AB - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n = 152, 128 women, 100–111 years; healthy controls: n = 343, 212 women, age <50 years; CAD controls: n = 98, 32 women, age ≤65 years) and Japanese (centenarians: n = 742, 623 women, 100–115 years; healthy controls: n = 920, 511 women, < 60 years; CAD controls: n = 395, 45 women, age ≤65 years). The frequency of the “risk” C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P = 0.088) or CAD controls (55.1 %, P = 0.078), and significant differences were found in genotype distributions (P = 0.034 and P = 0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P = 0.602), but it was significantly lower in the former than in CAD controls (57.2 %, P < 0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23–26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
KW - Genética humana
KW - Vejez
LA - eng
ER -