TY - JOUR A1 - Gilsanz Muñoz, María Fuencisla AU - Martínez Martínez, Mónica AU - Pérez Piñeiro, Javier AU - Roldán Matilla, Miriam AU - Arce García, Mariana Paula AU - Blasco Chicano, Rodrigo AU - Rico San Román, Laura AU - Esperón Fajardo, Fernando AU - Cerpa Naranjo, Arisbel AU - Martín-Maldonado Jiménez, Bárbara T1 - Assessing the Antimicrobial Efficacy of Graphene Oxide and Its PEGylated Derivative Against Staphylococcus Aureus Y1 - 2024 SN - 2413-4155 UR - http://hdl.handle.net/11268/13155 AB - The rise of antimicrobial resistance (AMR) has become a critical health challenge. This, plus the antimicrobial discovery void, had led scientists to search for an effective alternative to antimicro-bials. In this context, nanomaterials, such as graphene oxide (GO), a two-dimensional (2D) carbon molecule with oxidized functional groups, have been shown to interact physically and chemically with bacteria. Moreover, the addition of polyethylene glycol (PEG) to its surface enhances GO’s biocompatibility and water solubility, making it a promising candidate for biomedical applications. This study evaluates the antimicrobial efficacy of GO and its polyethylene glycol-modified form (GO-PEG) against Staphylococcus aureus, a bacterium responsible for numerous hospital-acquired and multidrug-resistant infections. After their production, both nanomaterials were characterized using various techniques to provide insight into their morphology, stability, and functional group composition. Then, the antimicrobial activity of GO and GO-PEG was assessed using the Müeller–Hinton broth microdilution method, determining the minimum inhibitory concentration (MIC) for S. aureus among ten different concentrations of both nanomaterials (from 0.0625 to 32 mg/mL). The results demonstrate the potential of GO as an effective antimicrobial agent at 16 and 32 mg/mL, offering new strategies in the fight against AMR. Further research could establish its role in future therapeutic applications. KW - Nanoestructuras KW - Staphylococcus aureus KW - Farmacorresistencia Microbiana KW - Ciencias médicas KW - Microbiología LA - eng ER -