TY - JOUR 
A1 - Sánchez Garrido, Isabel
AU - Ramírez, Lucía
AU - Muñoz Corcuera, Marta
AU - Garrido, Estela
AU - Sánchez, Lorenzo
AU - Martínez Acitores, María Luisa
AU - Hernández, Gonzalo
AU - López Pintor, Rosa María
T1 - Xerostomia and Salivary Dysfunction in Patients With  Diabetes Mellitus. A Cross-Sectional Study
Y1 - 2024
SN - 0904-2512

UR - http://hdl.handle.net/11268/13109
AB - Background: Diabetes mellitus (DM) has been associated with salivary disorders such as xerostomia and hyposalivation. 
The aim of this study was to determine the prevalence of these disorders and their risk factors in DM patients.
Methods: DM patients from two health centers were included. Epidemiological and DM control-related variables were collected. 
Xerostomia Inventory was filled out by the patients and unstimulated whole salivary flow was collected. Logistic regression tests 
were performed.
Results: A total of 168 patients were included (46.4% men, 53.6% women, mean age 72.54 [SD 11.03years]). Thirteen patients 
had Type 1 DM and 155 had Type 2 DM. 52.4% experienced xerostomia and 41.1% had unstimulated whole salivary flow hypos alivation. Women were more likely to suffer hyposalivation than men (OR 2.5, 95% CI 1.32–4.73; p=0.005). Patients with T2DM 
were less likely to suffer UWS hyposalivation than T1DM patients (OR 0.28, 95% CI 0.08–0.95; p=0.04). Glycemic control was 
not significantly worse in patients with xerostomia and hyposalivation. The drugs for the treatment of DM were not associated 
with salivary disorders. However, some drugs to treat other comorbidities such hypertension and neurological diseases were 
associated with xerostomia and hyposalivation.
Conclusions: The prevalence of xerostomia and unstimulated whole salivary flow hyposalivation in patients with DM is high. 
Female sex, T1DM, and the use of certain non-antidiabetic drugs increased the risk of suffering these disorders. The possible 
association between DM, xerostomia, and/or hyposalivation is complex and may be influenced by multiple factors. Therefore, 
further studies are needed to evaluate whether DM influences these salivary disorders
KW - Xerostomía
KW - Diabetes Mellitus
KW - Estudios de evaluación
KW - Odontología
KW - Sistema endocrino
LA - eng
ER -