TY - JOUR 
A1 - Riestra Ayora, Juan Ignacio
AU - Yanes Díaz, Joaquín
AU - Esteban Sánchez, Jonathan
AU - Vaduva, Cristina
AU - Molina Quiros, Cristina
AU - Larran Jiménez, Alba
AU - Martín Sanz, Eduardo
T1 - Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers
Y1 - 2021
SN - 0937-4477

UR - http://hdl.handle.net/11268/11554
AB - Purpose The study aimed to determine the incidence and long-term evolution of COVID-related olfactory (OD) and gustatory (GD) dysfunction, the recovery timeline, and the association with other symptoms. The secondary objective was to
identify the predictive clinical factors for the evolution of these symptoms.
Methods A prospective case–control study was conducted from March 15 to October 15, 2020, in health workers with
COVID-19 related symptoms in a tertiary care hospital. 320 patients were included after 6 months of follow-up: 195 in the
case group and 125 in the control group. Olfactory dysfunction (OD), dysosmia, and gustatory dysfunction (GD) onset and
recovery rate after 6 months follow-up are analyzed in both groups.
Results There were 125 (64.1%) in case group patients with OD and 118 (60.5%) with GD. Total or partial recovery OD
and GD was found in 89%, mainly in the frst 2 months. In the control group, there were 14 (11.2%) patients with OD and
33 (26.4%) patients with GD, with 100% of total/partial recovery.
Conclusion In both groups, OD and GD showed high-resolution rates during the frst two months after the onset of symptoms.
Nevertheless, 11% of the case group patients did not show any recovery, and the partial resolution was present in 30% of our
patients, at the 6 months follow-up. We found a high correlation between OD and GD, both in the appearance of symptoms
and in their recovery. Nasal obstruction and dyspnea have been identifed as risk factors for the persistence of symptoms.
KW - Infecciones por coronavirus
KW - Trastornos del olfato
KW - Trastornos del gusto
KW - Enfermedad transmisible
KW - Calidad de vida
LA - eng
ER -