TY - JOUR 
A1 - Martínez Sellés Oliveria Soares, Manuel
AU - Bruña Fernández, Vanesa
AU - Lacalzada Almeida, Juan
AU - Díez Villanueva, Pablo
AU - Ruiz Ortiz, Martín
AU - Alzola, Elisabete
AU - Arnau, Miguel Ángel
AU - Tobar, Javier
AU - Hernández, Jesús Manuel
AU - Pérez David, Esther
AU - Et al.
T1 - Rationale and design of the rigorous atrial analysis in advanced interatrial block (ARABIA) prospective study
Y1 - 2021
SN - 0022-0736

UR - http://hdl.handle.net/11268/11507
AB - Advanced interatrial block (IAB) is present in 10% of subjects ≥75 years and is associated with the risk of clinical events.

Methods and results: Prospective multicenter study that will include subjects ≥75 years without exclusion criteria (indication for anticoagulation, cardiac devices, severe valve disease, systolic dysfunction, moderate or severe cognitive impairment, poor echocardiographic window, non-sinus rhythm or partial IAB, stroke, and life expectancy <2 years). A total of 356 subjects, 178 patients with advanced IAB (exposed) and 178 matched individuals with normal P-wave (non-exposed) will be included. Electrocardiogram and advanced transthoracic echocardiography will be performed. Two substudies will include magnetic resonance imaging: cardiac (86 subjects, 43 exposed, and 43 non-exposed) and brain (86 subjects, 43 exposed, and 43 non-exposed). The follow-up will be 2 years. Our main objective is to determine the association of advanced IAB, P-wave duration, and atrial imaging parameters (I] atrial global longitudinal strain, II] maximal left atrial volume index, III] left atrial ejection fraction, IV] left atrial fibrosis - % total left atrial area V] inter- and intra-atrial asynchrony/dyssynchrony) with clinical events (atrial fibrillation, stroke, cognitive impairment, and mortality). The secondary objective is to assess the association of the P-wave duration with atrial imaging parameters and of both with cerebral microemboli in magnetic resonance imaging.

Conclusion: Our study will provide data regarding the association of advanced IAB, P-wave duration, and atrial imaging parameters with clinical events. We will also assess the association P-wave duration-atrial imaging parameters-cerebral microemboli.
KW - Fibrilación atrial
KW - Bloqueo interauricular
KW - Signos y síntomas
KW - Enfermedad cardiovascular
KW - Medicina preventiva
KW - Tratamiento médico
LA - eng
ER -