TY - JOUR 
A1 - Hernando Polo, Susana
AU - Moreno Muñoz, Diana
AU - Rosero Rodríguez, Adriana Carolina
AU - Silva Ruiz, Jorge
AU - Rosero Rodríguez, Diana Isabel
AU - Couñago Lorenzo, Felipe
T1 - Changing the History of Prostate Cancer with New Targeted Therapies
Y1 - 2021
SN - 2227-9059
UR - http://hdl.handle.net/11268/11372
AB - The therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC) is changing due to the emergence of new targeted therapies for the treatment of different molecular subtypes. Some biomarkers are described as potential molecular targets different from classic androgen receptors (AR). Approximately 20–25% of mCRPCs have somatic or germline alterations in DNA repair genes involved in homologous recombination. These subtypes are usually associated with more aggressive disease. Inhibitors of the enzyme poly ADP ribose polymerase (PARPi) have demonstrated an important benefit in the treatment of these subtypes of tumors. However, tumors that resistant to PARPi and wildtype BRCA tumors do not benefit from these therapies. Recent studies are exploring drug combinations with phosphatidylinositol-3-kinase (PI3K) or protein kinase B (AKT) inhibitors, as mechanisms to overcome resistance or to induce BRCAness and synthetic lethality. This article reviews various different novel strategies to improve outcomes in patients with prostate cancer.
KW - Neoplasias de la próstata
KW - Antineoplásicos hormonales
KW - Inmunoterapia
KW - Cáncer
KW - Tratamiento médico
LA - eng
ER -