TY - JOUR A1 - García Martín, Antonia AU - Varsavsky, Mariela AU - Cortés Berdonces, María AU - Ávila Rubio, Verónica AU - Alhambra Expósito, María Rosa AU - Novo Rodríguez, Cristina AU - Rozas Moreno, Pedro AU - Romero Muñoz, Manuel AU - Jódar Gimeno, José Esteban AU - Rodríguez Ortega, Pilar AU - Muñoz Torres, Manuel T1 - Phosphate disorders and the clinical management of hypophosphatemia and hyperphosphatemia Y1 - 2020 SN - 2530-0180 UR - http://hdl.handle.net/11268/11240 AB - Serum phosphorus levels range from 2.5 and 4.5 mg/dl (0.81–1.45 mmol/l) in adults, with higher levels in childhood, adolescence, and pregnancy. Intracellular phosphate is involved in intermediary metabolism and other essential cell functions, while extracellular phosphate is essential for bone matrix mineralization. Plasma phosphorus levels are maintained within a narrow range by regulation of intestinal absorption, redistribution, and renal tubular absorption of the mineral. Hypophosphatemia and hyperphosphatemia are common clinical situations, although changes are most often mild and oligosymptomatic. However, acute and severe conditions that require specific treatment may occur. In this document, members of the Mineral and Bone Metabolism Working Group of the Spanish Society of Endocrinology and Nutrition review phosphate disorders and provide algorithms for adequate clinical management of hypophosphatemia and hyperphosphatemia. KW - Hipofosfatemia KW - Hiperfosfatemia KW - Endocrinología KW - Nutrición LA - eng ER -