TY - JOUR 
A1 - Díaz Gavela, Ana Aurora
AU - Cerro, Elia del
AU - Sánchez García, Sofía
AU - Leonardo Guerrero, Luis
AU - Sanz Rosa, David
AU - Couñago Lorenzo, Felipe
T1 - Breast cancer radiotherapy: What physicians need to know in the era of the precision medicine
Y1 - 2021
SN - 0888-6008

UR - http://hdl.handle.net/11268/10564
AB - Abstract: Breast cancer is the most common cancer in women worldwide and encompasses a broad spectrum of diseases in one with significant epidemiological, clinical, and biological heterogeneity, which determines a different natural history and prognostic profile. Although classical tumour staging (TNM) still provides valuable information, the current reality is that the clinicians must consider other biological and molecular factors that directly influence treatment decision-making. The management of breast cancer has changed radically in the last 15 years due to significant advances in our understanding of these tumours. This knowledge has brought with it a major impact regarding surgical and systemic management and has been practice-changing, but it has also created significant uncertainties regarding how best integrate the radiotherapy treatment into the therapeutic scheme. In parallel, radiotherapy itself has also experienced major advances, new radiobiological concepts have emerged, and genomic data and other patient-specific factors must now be integrated into individualised treatment approaches. In this context, “precision medicine” seeks to provide an answer to these open questions and uncertainties. The aim of the present review is to clarify the meaning of this term and to critically evaluate its role and impact on contemporary breast cancer radiotherapy.
KW - Neoplasias de la mama
KW - Radioterapia
KW - Medicina de precisión
KW - Cáncer
KW - Radioquímica
LA - eng
ER -