TY - JOUR 
A1 - Couñago Lorenzo, Felipe
AU - Luna Tirado, Francisco Javier
AU - Guerrero Gómez, Luis Leonardo
AU - Vaquero Barrón, Blanca
AU - Guillén Sacoto, María Cecilia
AU - González Merino, Teresa
AU - Taboada, Begoña
AU - Díaz, Verónica
AU - Rubio Viqueira, Belén
AU - Díaz Gavela, Ana Aurora
AU - Marcos, Francisco José
AU - Cerro, Elia del
T1 - Management of oligometastatic non-small cell lung cancer patients: Current controversies and future directions
Y1 - 2019
SN - 2218-4333
UR - http://hdl.handle.net/11268/10512
AB - Oligometastatic non-small cell lung cancer (NSCLC) describes an intermediate stage of NSCLC between localized and widely-disseminated disease. This stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor biology. Currently, the management of oligometastatic NSCLC involves radical treatment (radiotherapy or surgery) that targets the metastatic lesions and the primary tumor to achieve disease control. This approach offers the potential to achieve prolonged survival in patients who, in the past, would have only received palliative measures. The optimal therapeutic strategies for the different scenarios of oligometastatic disease (intracranial vs extracranial disease, synchronous vs metachronous) remain undefined. Given the lack of head-to-head studies comparing radiotherapy to surgery in these patients, the decision to apply surgery or radiotherapy (with or without systemic treatment) must be based on prognostic factors that allow us to classify patients. This classification will allow us to select the most appropriate therapeutic strategy on an individualized basis. In the future, the molecular or microRNA profiles will likely improve the treatment selection process. The objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC, focusing on the role of radiotherapy and surgery. We also discuss areas of controversy and future directions.
KW - Metastasectomía
KW - Oncología por radiación
KW - Metástasis de la neoplasia
KW - Cáncer
KW - Aparato respiratorio
LA - eng
ER -