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dc.contributor.author | Ducrocq, Gregory | |
dc.contributor.author | Calvo, Gonzalo | |
dc.contributor.author | González Juanatey, José Ramón | |
dc.contributor.author | Durand Zaleski, Isabelle | |
dc.contributor.author | Avendano Sola, Cristina | |
dc.contributor.author | Puymirat, Etienne | |
dc.contributor.author | Lemesle, Gilles | |
dc.contributor.author | Arnáiz, Joan Albert | |
dc.contributor.author | Martínez Sellés Oliveria Soares, Manuel | |
dc.contributor.author | REALITY investigators | |
dc.contributor.author | Et al. | |
dc.date.accessioned | 2021-02-11T19:25:26Z | |
dc.date.available | 2021-02-11T19:25:26Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Ducrocq, G., Calvo, G., González-Juanatey, J. R., Durand-Zaleski, I., Avendano-Sola, C., Puymirat, E., Lemesle, G., Arnáiz, J. A., Martínez-Sellés, M., Rousseau, A., Cachanado, M., Vicaut, E., Silvain, J., Karam, C., Danchin, N., Simón, T., Steg, P. G., & REALITY investigators (2021). Restrictive vs liberal red blood cell transfusion strategies in patients with acute myocardial infarction and anemia: Rationale and design of the REALITY trial. Clinical Cardiology, 44(2), 143–150. https://doi.org/10.1002/clc.23453 | spa |
dc.identifier.issn | 1932-8737 | |
dc.identifier.issn | 0160-9289 | |
dc.identifier.uri | http://hdl.handle.net/11268/9842 | |
dc.description.abstract | Background: Anemia is common in patients with acute myocardial infarction (AMI), and is an independent predictor of mortality. The optimal transfusion strategy in these patients is unclear. Hypothesis: We hypothesized that a "restrictive" transfusion strategy (triggered by hemoglobin ≤8 g/dL) is clinically noninferior to a "liberal" transfusion strategy (triggered by hemoglobin ≤10 g/dL), but is less costly. Methods: REALITY is an international, randomized, multicenter, open-label trial comparing a restrictive vs a liberal transfusion strategy in patients with AMI and anemia. The primary outcome is the incremental cost-effectiveness ratio (ICER) at 30 days, using the primary composite clinical outcome of major adverse cardiovascular events (MACE; comprising all-cause death, nonfatal stroke, nonfatal recurrent myocardial infarction, or emergency revascularization prompted by ischemia) as the effectiveness criterion. Secondary outcomes include the ICER at 1 year, and MACE (and its components) at 30 days and at 1 year. Results: The trial aimed to enroll 630 patients. Based on estimated event rates of 11% in the restrictive group and 15% in the liberal group, this number will provide 80% power to demonstrate clinical noninferiority of the restrictive group, with a noninferiority margin corresponding to a relative risk equal to 1.25. The sample size will also provide 80% power to show the cost-effectiveness of the restrictive strategy at a threshold of €50 000 per quality-adjusted life year. Conclusions: REALITY will provide important guidance on the management of patients with AMI and anemia. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.subject.other | Insuficiencia cardíaca | spa |
dc.subject.other | Transfusión sanguínea | spa |
dc.subject.other | Reacción a la transfusión | spa |
dc.title | Restrictive vs liberal red blood cell transfusion strategies in patients with acute myocardial infarction and anemia: Rationale and design of the REALITY trial | spa |
dc.type | article | spa |
dc.description.impact | 3.287 JCR (2021) Q3, 74/143 Cardiac & Cardiovascular Systems | spa |
dc.description.impact | 0.983 SJR (2021) Q1, 82/356 Cardiology and Cardiovascular Medicine | spa |
dc.description.impact | No data IDR 2021 | spa |
dc.identifier.doi | 10.1002/clc.23453 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.unesco | Sistema cardiovascular | spa |
dc.subject.unesco | Enfermedad cardiovascular | spa |
dc.subject.unesco | Tratamiento médico | spa |
dc.description.filiation | UEM | spa |
dc.relation.publisherversion | http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1002/clc.23453 | spa |
dc.peerreviewed | Si | spa |
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