Resumen:
Introduction Cystic fibrosis is the most lethal autosomal recessive disease with higher prevalence in Caucasian population [1]. More than 1,800 mutations have been identified and can be clustered in six functional groups, therefore, altering the secretion and absorption in different tissues. Recurrent infections result in an increased damage to the lungs that leads to hypoxia in peripheric tissues such as skeletal muscle. Then, skeletal muscle weakness displays very early in patients with CF [2]. Recent studies have shown that CFTR protein is expressed in skeletal muscle, and therefore CF has a direct effect in this tissue [3]. Both respiratory damage and muscular weakness result in a reduced exercise capacity that will lead to exercise intolerance and reduction of expectoration and pulmonary function. Objective: Determine the effect of a strength exercise program on muscle function in children with CF. Methods: 17 pediatric patients with CF participated in a randomized, prospective, controlled design. They were divided in two groups: Control Group (CG) (n=9; Age 12.43 ± 3.78 years; follow standard medical care), and Exercise Group (EG) (n=8; Age 12.75 ± 3.06 years; follow 8 weeks of supervised e...