Resumen:
INTRODUCTION: Exercise is one of the main mitochondrial regulation factors. The number of mitochondria can increase by 50-100%
depending on the training program, improving the energy production capacity of the organism, thus, improving global health. Besides,
several genetic polymorphisms in the nuclear genes related to the PPARGC1A-NRF-TFAM mitochondrial biogenesis pathway have been
found to correlate with the elite athlete status and with other markers of physical performance and fitness. In addition, several authors have shown that alterations in mitochondrial biogenesis of tumor cells could be risk factors for cancer progression. Thus, the aim of this study is to analyze the frequency of the main genetic polymorphisms involved in these mitochondrial biogenesis pathways in samples of healthy women and women with colorectal cancer.
METHODS: We analyzed 84 DNA samples from tumors of women with colorectal cancer (group 1) and 449 DNA samples from peripheral
blood of healthy women as control group (group 2) paired by age with group 1. All the samples were ceded by the Spanish National DNA
Bank Carlos III (BNADN) and donated voluntarily after informed consent signature. The genetic polymorphi...