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dc.contributor.author | Postigo, Andrea | |
dc.contributor.author | Bermejo, Javier | |
dc.contributor.author | Muñoz, Patricia | |
dc.contributor.author | Valerio Minero, Maricela | |
dc.contributor.author | Marín, Mercedes | |
dc.contributor.author | Pinilla, Blanca | |
dc.contributor.author | Cuerpo, Gregorio | |
dc.contributor.author | Marí, Amaia | |
dc.contributor.author | Fernández Avilés, Francisco | |
dc.contributor.author | Martínez Sellés Oliveria Soares, Manuel | |
dc.contributor.author | Et al. | |
dc.date.accessioned | 2020-03-24T12:13:02Z | |
dc.date.available | 2020-03-24T12:13:02Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Postigo, A., Bermejo, J., Muñoz, P., Valerio, M., Marín, M., Pinilla, B., Cuerpo, G., Marí, A., Delgado Montero, A., Bouza, E., Fernández Avilés, F., & Martínez Sellés, M. (2020). Troponin elevation is very common in patients with infective endocarditis and is associated with a poor outcome. International Journal of Cardiology, 307, 82-86. https://doi.org/10.1016/j.ijcard.2020.02.029 | spa |
dc.identifier.issn | 0167-5273 | |
dc.identifier.issn | 1874-1754 | |
dc.identifier.uri | http://hdl.handle.net/11268/8829 | |
dc.description.abstract | Introduction We sought to study the prevalence of cardiac troponin T (TnT) elevation in patients with infective endocarditis (IE) and its association with in-hospital outcomes. Methods and results Retrospective single-center study. From 2008 to 2018, 528 patients were diagnosed with IE and 250 (47.3%) had at least a TnT determination during hospital admission, 103 with conventional TnT assay and 147 with high-sensitive assay. Elevated TnT levels were found in 210 patients (84.0%). Compared with patients with normal TnT levels, patients with TnT elevation presented higher in-hospital mortality (5 [12.5%] vs. 77 [36.7%], p < 0.001) and more frequent complications: heart failure (9 [22.5%] vs. 106 [50.5%], p < 0.001), cardiac abscesses (4 [10.0%] vs 58 [27.6%], p = 0.03), conduction disorders (0 vs. 26 [12,4%]; p = 0.04), and involvement of the central nervous system (1 [2.5%] vs. 38 [18.1%];p = 0.02). Patients with elevated TnT had more frequent indication for surgery (24 [60.0%] vs. 179 [85.2%], p < 0.001) and were operated on more frequently (16 [40.0%] vs 123 [58.6%], p = 0.03). TnT elevation was an independent predictor of in-hospital mortality (OR 3.31; 95% CI 1.02–10.72, p = 0.05). Adding TnT data to conventional clinical models improved the predictive capability of in-hospital mortality (R2: 0.407 vs. 0.388, χ2: 85.03 vs. 80.40, p < 0.001), resulting in a net reclassification improvement of 0.29 (95% CI: 0.13–0.46, p < 0.01). Conclusions TnT elevation is very common in patients with IE and is associated with increased in-hospital mortality and complications, thus routine monitoring should be recommended. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | spa | spa |
dc.title | Troponin elevation is very common in patients with infective endocarditis and is associated with a poor outcome | spa |
dc.type | article | spa |
dc.description.impact | 4.164 JCR (2020) Q2, 56/142 Cardiac & Cardiovascular Systems | spa |
dc.description.impact | 1.406 SJR (2020) Q1, 62/349 Cardiology and Cardiovascular Medicine | spa |
dc.description.impact | No data IDR 2020 | spa |
dc.identifier.doi | 10.1016/j.ijcard.2020.02.029 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Cardiología | spa |
dc.subject.uem | Enfermedades | spa |
dc.subject.uem | Proteínas | spa |
dc.subject.unesco | Enfermedad cardiovascular | spa |
dc.subject.unesco | Proteína | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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