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dc.contributor.author | Ramírez Jiménez, Miguel | |
dc.contributor.author | Fernández Elías, Valentín Emilio | |
dc.contributor.author | Morales Palomo, Félix | |
dc.contributor.author | Ortega Fonseca, Juan Fernando | |
dc.contributor.author | Mora Rodríguez, Ricardo | |
dc.date.accessioned | 2018-11-06T11:03:59Z | |
dc.date.available | 2018-11-06T11:03:59Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Ramirez-Jimenez, M., Fernandez-Elias, V., Morales-Palomo, F., Ortega, J. F., & Mora-Rodriguez, R. (2018). Intense aerobic exercise lowers blood pressure in individuals with metabolic syndrome taking antihypertensive medicine. Blood Pressure Monitoring, 23(5), 230-236. https://doi.org/10.1097/MBP.0000000000000328 | spa |
dc.identifier.issn | 359-5237 | |
dc.identifier.uri | http://hdl.handle.net/11268/7542 | |
dc.description.abstract | OBJECTIVE: There is a growing tendency for physicians to prescribe exercise in accordance with the 'exercise is medicine' global health initiative. However, the exercise-pharmacologic interactions for controlling blood pressure are not well described. Our purpose was to study whether angiotensin II receptor type 1 blocker (ARB) antihypertensive medicine enhances the blood pressure-lowering effects of intense exercise. PARTICIPANTS AND METHODS: Fifteen hypertensive individuals with metabolic syndrome chronically medicated with ARB underwent two exercise trials in a blind randomized order. One trial was conducted after taking their habitual dose of ARB (ARB MED trial) and another after 48 h of placebo medicine (i.e. dextrose; PLAC trial). RESULTS: After placebo medication, brachial systolic blood pressure increased by 5.5 mmHg [P=0.009; effect size (ES)=0.476] and diastolic by 2.5 mmHg (P=0.030; ES=0.373). Exercise reduced systolic and diastolic blood pressures to the same extent in ARB MED and PLAC trials (7 and 8 mmHg, respectively, for systolic and 5 and 4 mmHg, respectively, for diastolic, all P<0.05). Pulsatile measures of arterial stiffness did not reveal an interaction effect between exercise and medication. However, postocclusion reactive hyperemia increased after exercise only in the ARB MED trial (361±169 to 449±240% from baseline; P=0.033; ES=0.429). CONCLUSION: ARBs and a bout of intense exercise each have an independent effect on lowering blood pressure in hypertensive individuals, and these effects are additive. | spa |
dc.description.sponsorship | Ministerio de Economía, Industria y Competitividad (DEP2017-83244-R) | spa |
dc.language.iso | eng | spa |
dc.title | Intense aerobic exercise lowers blood pressure in individuals with metabolic syndrome taking antihypertensive medicine | spa |
dc.type | article | spa |
dc.description.impact | 1.008 JCR (2018) Q4, 62/65 Peripheral Vascular Disease | spa |
dc.description.impact | 0.538 SJR (2018) Q1, 2/9 Assessment and Diagnosis, 12/60 Advanced and Specialized Nursing; Q2, 178/365 Cardiology and Cardiovascular Medicine, 69/141 Internal Medicine, 1229/2844 Medicine (miscellaneous) | spa |
dc.description.impact | No data IDR 2018 | spa |
dc.identifier.doi | 10.1097/MBP.0000000000000328 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Presión sanguínea | spa |
dc.subject.uem | Ejercicio físico | spa |
dc.subject.unesco | Sistema cardiovascular | spa |
dc.subject.unesco | Deporte | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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